|
| |
|
The prognostic marker for cervical dysplasia!
State
of the Art
Human
papilloma viruses (HPV) are playing a decisive role at the
development of cervical cancer (carcinome). Therefore the easy and reliable
detection
(diagnosis) of HPV induced changes to the cells plays a vital role in
cancer prevention.
The routinely performed cytologic exam by pap smear (Papanicolaou staining), including coloscopy,
has played
a central part in the continuousreduction in the frequency of cervical
carcinoma cases.
 |
The L1 capsidprotein is a
nuclear protein that is rapidly transported into thenucleus of the cell
after it is synthesised in the cytoplasm. Therefore the nuclearstaining
is the specific staining. In addition to a strong nuclear staining
sometimesa
vesicular staining within the cytoplasm is observed too (ribosomes
producing the
L1 Capsidprotein). (see picture 2a). |
Thanks
to these procedures, characteristic changes in the cell structure, like dysplasia, can
be detected
years before an invasive carzinome originates.
Most dysplasia cases do not need to be treated in the first place as about 80% of
them regress spontaneously.
But as there are no morphological or molecularbiological criteria
indicating if there will be remission to a healthy state or a
progression towards cancer, the detection of dysplasia leads to a
variety of confusion in the patients.
The results are often excessive therapies with a large amount of
unnecessary surgery. The new prognostic marker cytoactiv®
provides now transparency and gives your patients the safe feeling to
be in good hands.
It all depends on the immune system
Latest research proves that by detecting the L1capsidprotein you can
predict the prognosis of adysplasia.
(Source:
Griesser et al.; AQCH, Vol. 26, No. 5, Oct 04, p. 241-245)
These observations can be explained by the biological properties of the
L1 capsidprotein that can be detected by cytoactiv®. If
cytoactiv® proves positive, a stimmulation of the immune system occurs
resulting in a consecutive healing of the dysplasia. If the
L1-capsidprotein can not be detected and there is no consecutive
stimulation of the immune system the dysplasia can develop into
cancer.
Multiple
applications -
Easy
and reliable
cytoactiv® is an immunochemical staining method, extremely simple and
robust in its application. The morphology of the cells remains
intact by this method so that you can do the evaluation under the
microscope as usual. One positively stained cell - detected by
its red nucleus - is sufficient for the positive result. You
can stain with the same staining protocol native smears, pap smears,
and monolayer slides as well as histologic sections.
|
A list of your advantages
-
The
prognostic
marker
for cervical dysplasia
-
Automizable staining and evaluation
-
Simple, fast and reliable results within 90
minutes
-
Can be processed in any cytologic
laboratory without the need of sophisticated equipment
|
| ART. CODE |
NAME |
SIZE |
CE MARKED |
| SCA1950 |
Cytoactiv
HPV L1 Screening Set
Immunochemical detection of the HPV L1 capsidprotein |
50
tests |
YES |
| SCA0850 |
Cytoactiv
HPV L1 high risk Set
Immunochemical detection of the HPV L1 capsidprotein of high risk types |
50
tests |
YES |
| |
|
|
|
| |
|
|
|
| Accessories |
| ART. CODE |
NAME |
SIZE |
CE MARKED |
| CAPZ5 |
HPV-Positive
control |
5
slides |
YES |
| CAWP50 |
wash buffer concentrate 20x concentrated |
125
ml |
YES |
| CAZP50 |
citric buffer concentrate
10x concentrated |
150
ml |
YES |
|
|
Cytoactiv
successfull! - Cytoactiv
registered in IRAN
|
|
The company Karestan Kala is sucessfully
distributing Cytoactiv on behalf of HHC in Iran.
Thanks to support from HHC and Cytoimmun, who provided kits for
registration and scientific material for workshops, Cytoactiv is
registered in Iran.
Further workshops and training sessions are organized by Karistan Kala
for practicians and professionals with increasing interest throughout
the country.
|
HHC is proud to cooperate with Karestan Kala
as high quality partner for the distribution of Cytoactiv.
Would you be interested, please do not hesitate to contact them :
|
Karestan Kala Co.,
Soraya Building ,
Unit 41, No.10, Pardis Street,
Molla Sadra Avenue ,
Tehran 1991915614, IRAN
Telephone: +98 (21) 88780591, 88875409
Fax: +98 (21) 88780596
Mr. Shadan Vilkiji, Chairman
e-mail : s_vilkiji@karestankala.com
Website: www.karestankala.com |
|
| |
| |
|
