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The BioNexia®
microalbumin test is an immune-chemical lateral flow test.
It serves the semi-quantitative detection of small quantities of
albumin in urine.
The steady expulsion of small quantities of
albumin with the urine can be the first sign of kidney damage. In the
healthy kidney albumin is usually glomerular fi ltrated and tubular
reabsorbed, so that it is hardly detectable in urine. With a damaged
kidney this process is disordered. The expulsion of albumin in the
range of 20 - 200 mg/L is characterized as microalbuminuria. With the
BioNexia<sup>®</sup> microalbumin test such
small concentrations are already securely captured.
Especially with diabetics positive results could point to a beginning
diabetic nephropathy. Without appropriate therapeutic intervention it
will lead for a high percentage of patients to a progression of this
complication. The expulsion of albumin increases continuously (=
macroalbuminuria) and ends finally after several years in a renal
failure, which makes dialysis or a kidney transplant inevitable. In the
USA and Europe diabetes is the main cause for terminal kidney failure.
A study (DEMAND), accomplished world-wide, shows that approx.
41% of type-2 diabetics exhibit a microalbuminuria. The frequency of
microalbuminuria increases with age, blood pressure and diabetes
duration, and is the rarer, the better the blood sugar is adjusted. The
high prevalence of the illness reveals how important a microalbuminuria
annual screening is for diabetics.
For type-1 diabetics the fi rst measurements are usually recommended 5
years after initiation of the illness. For type-2 diabetics the
screening should start directly with the fi rst outset of the
diagnosis, since it is unknown, how long the illness already exists.
The diagnosis of a microalbuminuria is also of special importance,
since it can be not only the fi rst sign of a beginning nephropathy but
also an indicator for an increased risk for cardiovascular illnesses
for type-2 diabetics.
An increase of albumin expulsion can be due, beside damages of renal
structures, to additional factors of infl uence like physical activity,
infections of the urinary tract, high blood pressure, heart insuffi
ciency or surgical interferences. If the increased albumin expulsion
disappears after removal of these factors, it concerns only a transient
albuminuria without any pathological reason.
Since the albumin expulsion can vary substantially from day to day, at
least 2 of 3 urine samples, which were collected over a period of 3-6
months, should show increased albumin values, before a microalbuminuria
is diagnosed.
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| ART. CODE |
NAME |
SIZE |
CE MARKED |
| BM-ALB-3S |
BioNexia
Micro Albumin Dipsticks |
20 dipsticks |
YES |
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The BioNexia®CRP
ratio Test is a semiquantitative rapid test for the detection and the
monitoring of CRP levels in whole blood samples. The cut-off of
detection of the test is 10 μg/ml.
CRP (C-reactive protein)
is an acute-phase-protein. It is a classical marker that can be used to
detect an inflammation re action in the body. CRP is synthesized
in the liver and is induced by proinflammatory cytokines, especially
Interleucin-6. Via the plasma, CRP is delivered to the sites of
inflammation, where it actively contributes to the innate immune
response. Systemic inflammation is usually accompanied by an increase
of CRP concentration in blood. Especially bacterial infections, sterile
tissue damage e.g. after surgical procedures, trauma or extreme
physical stress, tumors especially in the metastasing stage, some
autoimmune diseases as well as malignant systemic diseases (Hodgkin’s
and Non-Hodgkin’s Lymphoma) can induce a CRP increase. For diagnostic
purposes, CRP is often used to differentiate between viral and
bacterial infections, as the increase in CRP is more enhanced in
bacterial infections. CRP is also frequently used to monitor the
therapeutic effect of e.g. an antibiotic treatment.
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| ART. CODE |
NAME |
SIZE |
CE MARKED |
| BM-CRP-2S |
BioNexia CrP
ratio Dipsticks (10,40,80 ng/ml) |
10 tests |
YES |
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Do you have any other question? Contact us and we will help you.
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is available in our
our products
page.
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